Alma Boyd Takesue is a National Park Service biologist spearheading the efforts to save the islands' native creatures from invasive species. Her antagonist, Dave LaJoy, is a local businessman who is fiercely opposed to the killing of any animals whatsoever and will go to any lengths to subvert her plans. As their confrontation plays out in a series of scenes escalating in violence, drama, and danger, When the Killing's Done relates a richly humane tale about the dominion we attempt to exert, for better or worse, over the natural world.

T. C. Boyle's furious, apocalyptic novel is about the exploitation of nature by man and the catastrophic consequences. Boyle has evolved one of his oldest subjects, never was he so bitter and evil, never so serious.